Kevin A. Zwetsloot, Ph.D.

Department Rank:
Assistant Professor

Area:
Exercise Science

Office: Convocation Center 063
Email: zwetslootka@appstate.edu

Education

Post-doctoral research fellowship - University of Missouri, Columbia
Ph.D. in Bioenergetics - East Carolina University
M.A. in Physical Education - California State University, Chico
B.S. in Exercise Physiology - California State University, Chico

Teaching Specialties

No content available.

Current Courses Being Taught

ES 3450 - Advanced Exercise Physiology
ES 5000 - Introduction to Research Principles & Design

Professional Affiliations / Organizations

American Physiological Society
American College of Sports Medicine

Research Interests

My research focuses on the role inflammation plays in sarcopenia (the age-related loss of muscle mass and strength) and other pathologies associated with muscle wasting.

Selected Publications

Peer-Reviewed Research Papers:
1. Gavin, T.P., H.W. Stallings III, K.A. Zwetsloot, L.M. Westerkamp, N.A. Ryan, R.A. Moore, W.E. Pofahl, and R.C. Hickner. Lower capillary density, but no difference in VEGF expression in obese versus lean young skeletal muscle in humans. Journal of Applied Physiology. 98(1). 315-21. 2005.
2. Croley, A.N., K.A. Zwetsloot, L.M. Westerkamp, N.A. Ryan, A.M. Pendergast, R.C. Hickner, W.E. Pofahl, and T.P. Gavin. Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women. Journal of Applied Physiology. 99(5). 1872-1879. 2005.
3. Ryan, N.A., K.A. Zwetsloot, L.M. Westerkamp, R.C. Hickner, W.E. Pofahl, and T.P. Gavin. Lower skeletal muscle capillarization and VEGF expression in aged versus young men. Journal of Applied Physiology. 100(1). 178-185. 2006.
4. Gavin, T.P., L.M. Westerkamp, and K.A. Zwetsloot. Soleus, plantaris, and gastrocnemius VEGF mRNA responses to hypoxia and exercise are preserved in aged compared with young female C57BL/6 mice. Acta Physiologica. 188(2). 113-121. 2006.
5. Gavin, T.P., R.S. Ruster, J.A. Carrithers, K.A. Zwetsloot, R.M. Kraus, C.A. Evans, D.J. Knapp, J.L. Drew, J.S. McCartney, J.P. Garry, and R.C. Hickner. No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men. Journal of Physiology. 585(1). 231-239. 2007.
6. Zwetsloot, K.A., L.M. Westerkamp, B.F. Holmes, and T. P. Gavin. “AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise.” Journal of Physiology. 586(24). 6021-6035. 2008.
7. Lees, S.J., K.A. Zwetsloot, and F.W. Booth. “Muscle precursor cells isolated from aged rats exhibit an increased TNF-α response” Aging Cell. 8(1). 26-35. 2009.
8. Jump, S.S., T.E. Childs, K.A. Zwetsloot, F.W. Booth, and S.J. Lees. “FGF2-stimulated proliferation is lower in muscle precursor cells from old rats.” Experimental Physiology. 94(6). 739-748. 2009.
9. *Shanley, R.A., *K.A. Zwetsloot, T.E. Childs, S.J. Lees, and F.W. Booth. “IGF-I activates the mouse type IIb myosin heavy chain gene.” American Journal of Physiology – Cell Physiology. E-pub ahead of print. 2009. *-denotes authors contributed equally to this work.

Invited Reviews and Editorials:
1. Zwetsloot, K.A., M.J. Laye, and F.W. Booth. Novel epigenetic regulation of skeletal muscle myosin heavy chain genes. Focus on “Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading”. Editorial Focus. American Journal of Physiology – Cell Physiology. 296(7). C1-C3. 2009.
2. Booth, F.W. and K.A. Zwetsloot. “Basic concepts about Genes, Inactivity, and Aging.” Invited Review. Scandinavian Journal of Medicine & Science in Sports. In Press. 2009.